| Date | Location | Result | |
| May 07, 2022 | Salt Lake City, UT | Colorado Mesa 16, Westminster 10 | Box score |
| May 06, 2022 | Salt Lake City, UT | Colorado Mesa 17, CSU Pueblo 10 | Box score |
| Apr 30, 2022 | Salt Lake City, UT | Westminster 13, Colorado Mesa 10 | Box score |
| Apr 24, 2022 | Grand Junction, CO | Colorado Mesa 18, Adams State 5 | Box score |
| Apr 22, 2022 | Pueblo, Colo. | Colorado Mesa 10, CSU Pueblo 6 | Box score |
| Apr 16, 2022 | Kansas City, MO | Colorado Mesa 10, Rockhurst 5 | Box score |
| Apr 14, 2022 | Quincy, IL | Colorado Mesa 8, Quincy 4 | Box score |
| Apr 09, 2022 | Grand Junction, CO | Colorado Mesa 22, CSU Pueblo 6 | Box score |
| Apr 02, 2022 | Grand Junction, CO | Colorado Mesa 15, Colorado College 12 | Box score |
| Mar 25, 2022 | St. Augustine, Fla. | Colorado Mesa 25, Flagler 9 | Box score |
| Mar 23, 2022 | Melbourne, Fla. | Florida Tech 16, Colorado Mesa 15 | Box score |
| Mar 19, 2022 | Tampa, Fla. | Tampa 15, Colorado Mesa 12 | Box score |
| Mar 16, 2022 | West Palm Beach, Fla | Colorado Mesa 14, Palm Beach Atl. 10 | Box score |
| Mar 05, 2022 | Alamosa, Colo. | Colorado Mesa 21, Adams State 4 | Box score |
| Feb 27, 2022 | Grand Junction, CO | Colorado Mesa 16, Westminster 13 | Box score |
| Feb 14, 2022 | Hartsville, S.C. | Colorado Mesa 21, Coker 5 | Box score |
| Feb 12, 2022 | Jacksonville, Fla. | Rollins 16, Colorado Mesa 9 | Box score |
| Feb 09, 2022 | Huntsville, Ala. | Colorado Mesa 19, UAH 10 | Box score |