| Date | Location | Result | |
| 03/15/22 | Lubbock, TX | Black Hills St. 72, Colorado Mesa 62 | Box score |
| 03/13/22 | Lubbock, TX | Colorado Mesa 63, Lubbock Christian 62 | Box score |
| 03/12/22 | Lubbock, TX | Colorado Mesa 69, Tex. A&M-Kingsville 55 | Box score |
| 03/04/22 | Spearfish, SD | Regis (CO) 79, Colorado Mesa 76 (OT) | Box score |
| 03/01/22 | Grand Junction, CO | Colorado Mesa 77, MSU Denver 65 | Box score |
| 02/26/22 | Durango, CO | Colorado Mesa 81, Fort Lewis 75 (OT) | Box score |
| 02/24/22 | Gunnison, CO | Colorado Mesa 62, Western Colo. 57 | Box score |
| 02/19/22 | Grand Junction, CO | Colorado Mesa 72, Colo. Sch. of Mines 62 | Box score |
| 02/18/22 | Grand Junction, CO | Colorado Mesa 91, Regis (CO) 79 | Box score |
| 02/11/22 | Alamosa, CO | Colorado Mesa 73, Adams St. 65 | Box score |
| 02/05/22 | Grand Junction, CO | Colorado Mesa 70, South Dakota Mines 54 | Box score |
| 02/01/22 | Salt Lake City, UT | Colorado Mesa 63, Westminster (UT) 52 | Box score |
| 01/29/22 | Grand Junction, CO | Colorado Mesa 81, Western Colo. 72 | Box score |
| 01/28/22 | Grand Junction, CO | Fort Lewis 83, Colorado Mesa 77 | Box score |
| 01/22/22 | Denver, CO | Colorado Mesa 86, Regis (CO) 80 | Box score |
| 01/21/22 | Golden, CO | Colo. Sch. of Mines 68, Colorado Mesa 58 | Box score |
| 01/15/22 | Grand Junction, CO | Colorado Mesa 101, Colo. Christian 66 | Box score |
| 01/14/22 | Grand Junction, CO | MSU Denver 85, Colorado Mesa 84 (OT) | Box score |
| 01/09/22 | Spearfish, SD | Colorado Mesa 81, Black Hills St. 71 | Box score |
| 01/01/22 | Las Vegas, NM | Colorado Mesa 85, N.M. Highlands 61 | Box score |
| 12/31/21 | Colorado Springs, CO | Colorado Mesa 78, UC-Colo. Springs 71 | Box score |
| 12/18/21 | Grand Junction, CO | Colorado Mesa 85, Colorado St.-Pueblo 75 | Box score |
| 12/17/21 | Grand Junction, CO | Colorado Mesa 90, Adams St. 45 | Box score |
| 12/11/21 | Grand Junction, CO | Colorado Mesa 69, Chadron St. 66 | Box score |
| 12/10/21 | Grand Junction, CO | Black Hills St. 75, Colorado Mesa 73 (OT) | Box score |
| 12/05/21 | Denver, CO | MSU Denver 73, Colorado Mesa 50 | Box score |
| 12/04/21 | Lakewood, CO | Colorado Mesa 68, Colo. Christian 63 | Box score |
| 11/27/21 | Grand Junction, CO | Colorado Mesa 80, Simon Fraser 56 | Box score |
| 11/26/21 | Grand Junction, CO | Colorado Mesa 94, Our Lady of the Lake 56 | Box score |
| 11/19/21 | Gunnison, CO | Colorado Mesa 99, Washington Adventist 59 | Box score |
| 11/13/21 | Gunnison, CO | Colorado Mesa 84, St. Edward's 77 | Box score |
| 11/12/21 | Dallas, TX | DBU 63, Colorado Mesa 56 | Box score |
| 10/31/21 | Canyon, TX | MSU Moorhead 81, Colorado Mesa 71 | Box score |
| 10/30/21 | Canyon, TX | Colorado Mesa 76, Daemen 65 | Box score |
| 10/29/21 | Canyon, TX | West Tex. A&M 72, Colorado Mesa 63 | Box score |
| 11/20/21 | Gunnison, CO | Colorado Mesa 106, Southwest (NM) 52 | Box score |