| Date | Location | Result | |
| 03/13/21 | Golden, CO | Northwest Nazarene 74, Colorado Mesa 54 | Box score |
| 03/06/21 | Grand Junction, CO | Colorado Mesa 75, Colo. School of Mines 74 (OT) | Box score |
| 03/05/21 | Grand Junction, CO | Colorado Mesa 78, Adams St. 66 | Box score |
| 03/02/21 | Grand Junction, CO | Colorado Mesa 67, Chadron St. 52 | Box score |
| 02/27/21 | Grand Junction, CO | Colorado Mesa 78, Fort Lewis 58 | Box score |
| 02/26/21 | Grand Junction, CO | Colorado Mesa 93, Western Colo. 77 | Box score |
| 02/20/21 | Golden, Colo. (Lockridge Arena) | Colorado Mesa 64, Colo. School of Mines 58 | Box score |
| 02/19/21 | Denver, CO | Colorado Mesa 73, Regis (CO) 63 | Box score |
| 02/13/21 | Grand Junction, CO | Colorado Mesa 80, Adams St. 66 (OT) | Box score |
| 02/05/21 | Rapid City, SD | Colorado Mesa 82, South Dakota Mines 77 (2OT) | Box score |
| 02/02/21 | Grand Junction, CO | Colorado Mesa 63, Westminster (UT) 60 | Box score |
| 01/30/21 | Gunnison, CO | Western Colo. 78, Colorado Mesa 72 | Box score |
| 01/29/21 | Durango, CO | Colorado Mesa 74, Fort Lewis 72 (OT) | Box score |
| 01/23/21 | Grand Junction, CO | Colorado Mesa 81, Regis (CO) 80 (OT) | Box score |
| 01/16/21 | Lakewood, CO | Colorado Mesa 78, Colo. Christian 67 | Box score |
| 1/15/21 | Auraria Event Center | Colorado Mesa 72, MSU Denver 57 | Box score |
| 01/04/21 | Grand Junction, CO | Colorado Mesa 60, UC-Colo. Springs 56 | Box score |
| 12/19/20 | Pueblo, CO | Colorado Mesa 76, Colorado St.-Pueblo 67 | Box score |
| 12/18/20 | Alamosa, CO | Colorado Mesa 100, Adams St. 98 | Box score |
| 12/12/20 | Chadron, NE | Colorado Mesa 77, Chadron St. 68 (2OT) | Box score |
| 12/11/20 | Spearfish, SD | Colorado Mesa 75, Black Hills St. 70 | Box score |
| 12/05/20 | Grand Junction, CO | Colorado Mesa 83, MSU Denver 68 | Box score |
| 12/04/20 | Grand Junction, CO | Colorado Mesa 80, Colo. Christian 60 | Box score |