| Date | Location | Result | |
| May 21, 2021 | Commerce, TX | Tex. A&M-Commerce 3, Colorado Mesa 1 | Box score |
| May 19, 2021 | Commerce, TX | Colorado Mesa 9, Angelo St. 2 | Box score |
| May 19, 2021 | Commerce, TX | Tex. A&M-Commerce 4, Colorado Mesa 3 | Box score |
| May 15, 2021 | Grand Junction, CO | Colorado Mesa 9, Colorado Christian 7 | Box score |
| May 15, 2021 | Grand Junction, CO | Colorado Mesa 9, Colorado Christian 3 | Box score |
| May 15, 2021 | Grand Junction, CO | Colorado Mesa 8, Regis 0 | Box score |
| May 14, 2021 | Grand Junction, CO | Colorado Christian 8, Colorado Mesa 0 | Box score |
| May 13, 2021 | Grand Junction, CO | Colorado Mesa 2, Colo. Sch. of Mines 1 | Box score |
| May 01, 2021 | Chadron, NE | Colorado Mesa 10, Chadron State 0 | Box score |
| May 01, 2021 | Chadron, NE | Colorado Mesa 7, Chadron State 0 | Box score |
| Apr 30, 2021 | Chadron, NE | Colorado Mesa 11, Chadron State 10 | Box score |
| Apr 30, 2021 | Chadron, NE | Colorado Mesa 15, Chadron State 2 | Box score |
| Apr 25, 2021 | Grand Junction, CO | Colorado Mesa 6, Colorado Christian 1 | Box score |
| Apr 25, 2021 | Grand Junction, CO | Colorado Mesa 8, Colorado Christian 6 | Box score |
| Apr 24, 2021 | Grand Junction, CO | Colorado Mesa 2, Colorado Christian 0 | Box score |
| Apr 24, 2021 | Grand Junction, CO | Colorado Mesa 7, Colorado Christian 2 | Box score |
| Apr 18, 2021 | Grand Junction, CO | Colorado Mesa 11, UCCS 3 | Box score |
| Apr 18, 2021 | Grand Junction, CO | Colorado Mesa 14, UCCS 4 | Box score |
| Apr 17, 2021 | Grand Junction, CO | UCCS 4, Colorado Mesa 3 | Box score |
| Apr 17, 2021 | Grand Junction, CO | Colorado Mesa 9, UCCS 2 | Box score |
| Apr 11, 2021 | Spearfish, S.D. | Colorado Mesa 11, Black Hills State 3 | Box score |
| Apr 10, 2021 | Spearfish, S.D. | Colorado Mesa 13, Black Hills State 3 | Box score |
| Apr 10, 2021 | Spearfish, S.D. | Colorado Mesa 20, Black Hills State 0 | Box score |
| Apr 10, 2021 | Spearfish, S.D. | Colorado Mesa 8, Black Hills State 3 | Box score |
| Apr 03, 2021 | Grand Junction, CO | Colorado Mesa 13, N.M. Highlands 1 | Box score |
| Apr 03, 2021 | Grand Junction, CO | Colorado Mesa 11, N.M. Highlands 3 | Box score |
| Apr 02, 2021 | Grand Junction, CO | Colorado Mesa 10, N.M. Highlands 6 | Box score |
| Apr 02, 2021 | Grand Junction, CO | Colorado Mesa 10, N.M. Highlands 1 | Box score |
| Mar 29, 2021 | Denver, Colo. | Colorado Mesa 12, Regis 1 | Box score |
| Mar 29, 2021 | Denver, Colo. | Regis 12, Colorado Mesa 6 | Box score |
| Mar 28, 2021 | Denver, Colo. | Colorado Mesa 6, Regis 0 | Box score |
| Mar 28, 2021 | Denver, Colo. | Colorado Mesa 10, Regis 8 | Box score |
| Mar 21, 2021 | Grand Junction, CO | Colorado Mesa 8, Adams State 0 | Box score |
| Mar 21, 2021 | Grand Junction, CO | Colorado Mesa 13, Adams State 2 | Box score |
| Mar 20, 2021 | Grand Junction, CO | Colorado Mesa 14, Adams State 6 | Box score |
| Mar 20, 2021 | Grand Junction, CO | Colorado Mesa 12, Adams State 4 | Box score |
| Mar 07, 2021 | Grand Junction, CO | Colorado Mesa 10, Colo. Sch. of Mines 2 | Box score |
| Mar 07, 2021 | Grand Junction, CO | Colorado Mesa 7, Colo. Sch. of Mines 3 | Box score |
| Mar 06, 2021 | Grand Junction, CO | Colorado Mesa 9, Colo. Sch. of Mines 8 | Box score |
| Mar 06, 2021 | Grand Junction, CO | Colorado Mesa 18, Colo. Sch. of Mines 0 | Box score |
| Mar 01, 2021 | Denver, CO | Colorado Mesa 13, MSU Denver 2 | Box score |
| Mar 01, 2021 | Denver, CO | Colorado Mesa 11, MSU Denver 10 | Box score |
| Feb 28, 2021 | Denver, CO | Colorado Mesa 2, MSU Denver 1 | Box score |
| Feb 28, 2021 | Denver, CO | Colorado Mesa 3, MSU Denver 0 | Box score |